In any event, NTLite's description needs more context because it doesn't apply to every random game.
<S2491>Fullscreen optimization for DX10/DX11 games</S2491>
DirectX Developer Blog/Updates in Graphics and Gaming
<S2491>Fullscreen optimization for DX10/DX11 games</S2491>
DirectX Developer Blog/Updates in Graphics and Gaming
– this setting affects presentation modes used in Windowed and Borderless Windowed DX10/DX11 games.
You don’t need to worry about DX12 games as they already take advantage of the new presentation mode.