I thought I'd chip in on this. I came a cross this topic since I am experiencing audio drop-outs as well. Mainly when gaming.
First, thank you
Hellbovine for managing this thread and spending so much effort into troubleshooting, and of also others for sharing valuable insights.
When I run Latencymon for 5 minutes after a fresh reboot all seems fine (see attachments 1 and 2). However when playing Red Dead Redemption 2 and Cities Skylines I experience regular audio drop-outs with DPC peaks in the 2000 - 3000's with nvlddmkm.sys being the culprit (see attachment 3).
When I am producing music in Ableton Live 11 I don't experience any audible clicks and pops. (will do a Latencymon test later).
One major change I've made recently is cloning my SATA 600 SSD (500GB) to a M.2 Samsung Evo Plus 970 SSD (2TB). I've used Macrium Reflect software for the cloning process. I doubt this contributes to the problem since I've had clicks and pops before with other games, but I'll mention it anyway.
I haven't tried the IrqPolicy and MSI mode settings yet, since I haven't had the time to read into it, but I'll try that next.
My setup:
PC Type: Desktop
Operating System/Version: Windows 10 64-bit 21H2
MOBO: MSI B450 Tomahawk
Processor: AMD Ryzen 7 5800x
Audio: Focusrite Scarlett 8i6 (driver 4.102.4)
Storage: Samsung 970 Evo Plus 2TB
Graphics: Nvidia RTX 3060 TI
Driver Type: Game Ready
Driver Version: 527.56
DPC Spikes: 450 (after reboot) 2000-3000 (when gaming)