We discussed it a bit in another thread (
link1), and a quick summary is that these tweaks are of particular interest for online gamers, because the settings can interfere in complex scenarios (games/networking/anti-cheat/etcetera) quite a bit, causing performance issues.
As Necrosaro mentions, I too have them all disabled, but with DEP enabled, and no issues in the last two years on W10 21H2 and 22H2. I have a number of posts (
link2) showing DPC latency benchmarks, and my machines always have significantly less latency overall compared to a stock Windows install, so this stuff does add up and make a difference, even if you don't notice a change when altering only a setting or two.