You mean would it deactivate, or is it breaking the terms of license?
First one no, the second one depends on your country, but usually no - do not distribute such Windows and you'll be ok.
And third if you're asking will you be able to activate, to make sure keep Components - toolbar - Compatibility - Windows Activation (and KMS) enabled.
Also keep OOBE compatibility enabled, after loading his presets, I noticed a few times it removed too much regarding Windows setup for a certain Win10 flavor.